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India’s fight against anaemia picks up pace, but states need to do more

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It was past 2 p.m. Khusbu Chaudhari, 24, seven months pregnant, was lying on a bed in the general ward at the Ballabhgarh Government Hospital in Haryana’s Faridabad. A thin plastic bag with her medical file lay next to her.


Seven days before, when Chaudhari had first visited the hospital after moving here from her mother’s home in Mumbai, her haemoglobin was 8.2 gm/dL–much below the normal range (12-16 gm/dL) for women. This meant she had moderate anaemia–which, during pregnancy, can be very risky for her and her child.




A health assistant herself, Chaudhari did not want to take chances–she had an emergency caesarean section in 2017 when her first child was born.


Her doctor prescribed three doses of intravenous iron sucrose–a new strategy to treat iron-deficiency anaemia during pregnancy, under the Centre’s Anaemia Mukt Bharat initiative. The day we visited the hospital, Chaudhari was given her second dose at noon, and was under observation.


Like Chaudhari, more than half of all pregnant women (50.3 per cent) in India were anaemic in 2015-16. Yet, only 30.3 per cent of pregnant women took iron and folic acid tablets for more than 100 days of pregnancy, according to the National Family Health Survey, 2015-16 (NFHS-4). Hence, new strategies under the Anaemia Mukt Bharat initiatives are vital to maternal health–anaemia was the direct cause in 20 per cent of maternal deaths and the associated cause in 50 per cent of deaths in India, as IndiaSpend reported in October 2016.


Anaemia Mukt Bharat, a new game plan to fight a longstanding disease

India had programmes to fight anaemia since 1970, when the National Anaemia Prophylaxis Programme was launched–it focused on distributing iron and folic acid (IFA) tablets to pregnant women, and children under five. In 2013, the government launched the weekly IFA supplementation programme for adolescents.


However, as we said, only three in 10 pregnant Indian women took IFA tablets for more than 100 days of pregnancy and only a quarter of children under five took iron supplements, according to NFHS-4. Inadequate supply of IFA tablets and disparity in distribution were some of the reasons for poor uptake, studies (here and here) found.


Not just in pregnancy, anaemia is widespread in India: More than half of women in reproductive age are anaemic (53 per cent) as are 22.7 per cent of men and 58.4 per cent of children under two.


Anaemia occurs when the concentration of haemoglobin–cells that transport oxygen–in blood decreases. With oxygen not reaching all organs and tissues of the body, the person feels tired, weak and is more prone to infections.


Nearly 50 per cent of anaemia is due to iron deficiency, especially in women and children. Other causes include infections such as malaria and tuberculosis, haemoglobinopathies–blood disorders that affect red blood cells, such as thalassemia–and deficiencies of other nutrients such as B12, folate and vitamin A.


Anaemia affects the cognitive development, behaviour, and physical growth of infants, preschool and school-aged children. It weakens immunity in all age groups and impacts the ability for physical work in adolescents and adults.


The loss of gross domestic product to anaemia was estimated at $22.64 billion (Rs 1.5 lakh crore) in 2016, more than three times the health budget for 2017-18, as IndiaSpend reported in November 2017.


During pregnancy, anaemia increases the risk for maternal mortality, preterm birth and infant mortality.


Anaemia Mukt Bharat added emphasis to the failure of previous approaches, and addressed them by introducing critical monitoring to fill implementation gaps. Launched in March 2018 along with POSHAN Abhiyan, the National Nutrition Mission, Anaemia Mukt Bharat aims to reduce anaemia prevalence by three percentage points per year among children, adolescents and women of reproductive age (15-49 years) by 2022.


Is anaemia finally getting the attention it deserves?

“It is indeed,” said Purnima Menon, senior research fellow, International Food and Policy Research Institute (IFPRI). The lack of progress on tackling anaemia between 2006 and 2016 was a real wake-up call to the nutrition and health community, she said.


The strategy devised under Anaemia Mukt Bharat is called ‘6X6X6’–with a focus on six interventions, six groups of beneficiaries and six institutional mechanisms.


Six beneficiaries included in Anaemia Mukt Bharat strategy are children below five, adolescent boys and girls aged 15-19 years, pregnant and lactating women, and women in reproductive age (15-49 years).


Six institutional mechanisms include intra-ministerial coordination, anaemia control unit, Centre for Excellence and Advanced Research on Anaemia Control, convergence with other ministries, strengthening supply chain logistics and Anaemia Mukt Bharat dashboard and online portal.


The interventions include deworming, intensified year-round behaviour change communication campaign, testing and treatment of anaemia using digital methods and point-of-care treatment, mandatory provision of IFA fortified foods in government programmes and intensified awareness screening, and treatment of non-nutritional causes of anaemia–especially malaria and other haemoglobinopathies.


The most important of these is making available the IFA supplementation across the states, said Ajay Khera, deputy commissioner for Child Health and Immunisation under the Ministry of Health and Family Welfare. While earlier programmes existed for 30 years, the reduction of anaemia has been just 1 percentage point per year, because the coverage of the supplements was about 20 per cent, he said.


“This time around there is strong supply-chain mechanism to ensure that there is IFA tablet for each child, pregnant women and adolescent girl irrespective of the anaemia level,” Khera added.


The most important of the interventions is providing iron and folic acid supplementation across states, says Ajay Khera, deputy commissioner for Child Health and Immunisation at the Ministry of Health and Family Welfare.

“It’s not clear yet how well the work on non-nutrition causes (of anaemia) is moving,” Menon said. “And the data on the non-nutritional causes still needs to be released so that a geographically nuanced diagnosis can be done.” The Comprehensive National Nutrition Survey–started in 2016 to evaluate the nutritional status of children and adolescents–is ready, but not yet released.


There is also stronger monitoring with the Anaemia Mukt Bharat dashboard that displays statewise data on availability, and coverage of IFA across different groups. “Every quarter we are relaying the data back to the states so there is [a] continuous monitoring mechanism,” Khera said.


“While dashboards are good to visualise data, we don’t know enough about how the dashboards are being used, who is looking at them, and what kind of actions are being taken,” said Menon of IFPRI. The intended users of the dashboards often need support to walk through the data and understand what actions should be taken, IFPRI research shows.


‘Test-Treat-Talk’ camps

The Test-Treat-Talk (T3) anaemia camp is a key strategy to generate demand and mobilise people. Held across the country since 2018, these camps use a digital hemoglobinometer to test for anaemia, give IFA tablets to treat, and counsel beneficiaries on lifestyle measures to increase iron levels in the body, and on foods rich in iron, protein and vitamin C.


In 2018, 900 camps were conducted nationwide which reached 100,000 people. In March 2019, 196,000 camps were held that reached 16.5 million people. In September 2019, during the nutrition month, T3 camps are expected to be held in government schools, colleges and institutions across India.



The Test-Treat-Talk (T3) anaemia camp is a key strategy to generate demand and mobilise people.

“Till now people didn’t know about anaemia or their own haemoglobin level,” said Khera. “This is a way for them to know their levels and also how to correct anaemia with supplements.”

The success of the camps has much to do with the adoption of the digital hemoglobinometer that allows instant haemoglobin testing. Conventionally, using laboratory facilities, it took up to three days for a patient to get their results–which led to poor testing and compliance, said Kapil Yadav, Associate Professor, Community Medicine at the All India Institute of Medical Sciences (AIIMS).


Progress slow, states allot a third of required funds

Nearly nine in 10 pregnant women (87.1 per cent) are receiving IFA supplementation regularly, according to the Anaemia Mukt Bharat dashboard.


Progress has been slow in IFA coverage for children and adolescents: In 2018-19, only 9.4 per cent of children below five received IFA supplementation, as did 17.9 per cent children up to nine years and 27.4 per cent adolescents.


Poor financial planning may have led to poor coverage, a UNICEF evaluation found. Most states did not plan for activities such as research, innovation, drug and warehouse logistics and human resources needed for the intensified initiative, the evaluation found.


States proposed only 36 per cent of the required budget to achieve 100 per cent coverage. While Rs 2,087 crore would have been required to reach all 407 million beneficiaries, only Rs 742 crore was proposed and Rs 574 crore was allocated.


Uttar Pradesh had a shortage of 87 per cent–highest nationwide–followed by Gujarat (65 per cent). While Jharkhand had no shortage, Maharashtra (19 per cent) and Chhattisgarh (19 per cent) had the lowest planning gap.


The researchers proposed that financing planning needs to be a part of Anaemia Mukt Bharat trainings and that states should plan for 100 per cent coverage, and coverage based on their previous records.


Getting iron directly into the bloodstream

Administering iron intravenously to pregnant women with anaemia is a rapid way to meet the iron requirements essential for pregnancy and lactation. This is difficult to achieve in a short span by oral iron supplements.


At the Ballabhgarh hospital, every day, 50 pregnant or lactating women receive iron sucrose at the ward. Since 2014, the centre has administered more than 20,000 infusions, and provided evidence for the efficacy and safety of the intervention to fight anaemia in pregnant women.


The district hospital at Ballabhgarh is run under the Comprehensive Rural Health Services Project, a collaboration between AIIMS and the Haryana government. The Community Medicine department at AIIMS also houses the National Centre for Excellence and Advanced Research in Anaemia Control, which provides the technical inputs required for Anaemia Mukt Bharat.


Patients being administered intravenous iron sucrose at Faridabad’s Ballabgarh Government Hospital. Every day, 50 pregnant or lactating women receive iron sucrose here.


“Since we started administering iron sucrose to pregnant women with anaemia, almost all the women that come for delivery [in the centre] have normal levels of haemoglobin,” said Sunita Malik, 49, nurse-in-charge of the general ward at the hospital. “This means the women have lower risk of haemorrhage during delivery and less need for blood transfusion,” she added. Even lactating mothers are given iron sucrose if they are anaemic, as the baby will receive iron from the mother.


Gomathi Ramaswamy, research officer, and Kapil Yadav, nodal officer, of the National Centre of Excellence and Advanced Research on Anaemia Control, at the Ballabgarh Government Hospital, Faridabad.


Earlier, only tertiary care centres with specialists were thought to be able to administer intravenous iron. “But our [AIIMS] research has shown iron sucrose is safe to be given in a primary healthcare setting where deliveries occur,” said Yadav, the AIIMS associate professor, adding that in the 12 primary health centres that AIIMS runs, 5,000 infusions of iron sucrose have been given

“This is especially important given than pregnant women with severe anaemia would then require blood transfusion, which is difficult in a rural setting given paucity of blood banks,” Yadav added.


Back in the Ballabgarh Government Hospital, Chaudhari’s haemoglobin levels will be checked after she receives her third dose of iron sucrose at the end of the month. If she has adequate iron levels, she will need no further intervention. Chaudhari and her unborn child will have adequate iron levels to ward off anaemia for some time to come.



Reporting for this story has been supported by ROSHNI-Centre of Women Collectives Led Social Action.


This story was first published here on Healthcheck.


(Yadavar is a special correspondent with IndiaSpend.)


We welcome feedback. Please write to [email protected] We reserve the right to edit responses for language and grammar.


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4 of 5 Indian children do not survive cancer. What led to this sorry state?

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How long does a cancer diagnosis take?


Six months, according to Bipin Jana, 45, whose eight-year-old son Parmeshwar has stage-4 Hodgkin’s lymphoma. That is how long it took the family, travelling 2,000 km across West Bengal, New Delhi and finally, Mumbai, to get an effective diagnosis and start treatment.


Parmeshwar is currently undergoing chemotherapy at the Tata Memorial Hospital (TMH), Mumbai, India’s foremost

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Vitamins and omega-3 fatty acids may help children with autism

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Children with autism who take supplements of vitamins and omega-3 fatty acids may have fewer symptoms than kids who don’t, a research review suggests.


Researchers examined data from 27 trials involving a total of 1,028 children with autism spectrum disorder. Kids were randomly selected to take various dietary supplements, including vitamins or omega-3s, or to take a dummy pill instead.


Omega-3s and vitamin supplements were more effective than the placebo pill at improving several symptoms, functions, and clinical domains, researchers report in Pediatrics. Gains varied in the trials but included improved language and social skills, reduced repetitive behaviours, improved attention, less irritability and behaviour difficulties, and better sleep and communication.


“These results suggest that some dietary interventions could play a role in the clinical management of some areas of dysfunction specific to ASD,” said David Fraguas, lead author of the study and a researcher at Hospital General Universitario Gregorio Maranon and Universidad Complutense de Madrid in Spain.


Even though the analysis was based on controlled experiments — the gold standard for testing the effectiveness of medical interventions — the individual studies were too varied in what supplements they tested and how they measured results to draw any broad conclusions about what type or amount of supplements might be ideal for children with autism, researchers note in Pediatrics.


“The underlying mechanisms involved in the potential efficacy of dietary interventions in autism spectrum disorder are unknown, Fraguas said by email. “Our study does not assess this important question and current literature is inconclusive.”


reuters


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New transplant research aims to salvage infected donated organs

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Retired subway and bus driver Stanley De Freitas had just celebrated his 70th birthday when he started coughing, tiring easily and feeling short of breath. He was diagnosed with pulmonary fibrosis, a severe scarring of the lungs, and put on the wait list for a transplant.


“Life became unbearable. From the time I got up in the morning until when I went to bed at night, I struggled through every breath of air,” De Freitas, now 74, told Reuters by phone from his home in Toronto.


After two years, De Freitas was offered a lung, with one significant downside: The donor had hepatitis C.


In October 2017, he became the first patient enrolled in a just published study conducted at Toronto General Hospital testing a technique that aimed to flush out and inactivate the hepatitis C virus from donor lungs before a transplant.


The research comes amid a spike in available organs linked to the opioid overdose crisis, meaning many are contaminated by hepatitis C as the virus is commonly spread by sharing needles. Since it can easily infect an organ recipient, those organs are usually discarded despite the urgent need.


Data from the United Network for Organ Sharing (UNOS), which matches donors with recipients, shows that 97 percent of people waiting for a lung in the United States last year were unwilling to accept an organ from a donor who tested positive for hepatitis C.


While hepatitis C causes serious liver disease, the virus can be present in the blood in other organs.


Researchers are testing different approaches to salvage infected organs.


A study published in April showed that giving patients antiviral therapy just hours after transplant surgery can successfully attack the virus before it gains a foothold in the recipient.


Eliminating the virus prior to transplant would simplify the procedure for patients, said UNOS Chief Medical Officer David Klassen. It could also significantly cut down on wasted donor organs.


The technique used in Toronto, known as ex vivo lung perfusion, keeps organs “alive” outside the body by pumping them with a bloodless oxygenated liquid. They used ultraviolet C light to irradiate the solution, aiming to deactivate the hepatitis C virus and make it non-infectious.


Perfusion allows doctors to evaluate and potentially rehabilitate organs for transplant, and buys them more time than storage in ice boxes, which can cause tissue damage.


Toronto researchers used a solution from Sweden’s Xvivo Perfusion AB with the hospital’s own ex vivo lung perfusion system, a bubble-like machine made from off-the-shelf components and an intensive care ventilator.


The study of 22 patients, published in The Lancet Respiratory Medicine on Wednesday, had mixed results. Adding light therapy significantly decreased the amount of virus, but all but two of the patients contracted hepatitis C, which is now curable.


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